This is not a fundraiser. “Run to stop cancer” is scientifically sound advice.
Unlike diabetes and coronary disease, which predictably prey upon the overweight and out-of-shape, cancer may seem to strike out of the blue, affecting the young and healthy as well as the wanton. And since cancer is fundamentally a genetic disease, it’s easy to feel helpless to combat a potential death sentence inscribed in your DNA.
But as Aaron Carroll points out, science is showing that genes alone do not account for even half of all cancer risk:
Using sophisticated modeling techniques, the researchers argued that less than 30 percent of the lifetime risk of getting cancer was because of intrinsic risk factors, or “bad luck.” (NYT/Nature)
Another study from JAMA Oncology found that 25% of cancers in women and 33% in men were potentially preventable by lifestyle modification: smoking cessation, moderation of alcohol intake, maintenance of healthy body weight, and regular exercise.
So lifestyle choices like diet and exercise seem to play as big a role as genetics in moderating cancer risk at the population level. There are individual cases where genetic mutations wholly predetermine cancer occurrence, but the vast majority of cancer types have a lifestyle-risk element. This should be a message of empowerment. Cancer is not destiny; we can and should use our powerful tools of lifestyle change to prevent cancer before it happens.
For details on the adrenalin theory of how exercise fights cancer, check out this piece in The Economist.
Lin-Manuel Miranda’s Hamilton will go down as one of the major artistic achievements of the decade (century?) The combination of subject matter (the Founding of the nation), social significance (a non-white cast and composer telling the story of our all-white Founding Fathers), and theatrical greatness (a mix of hip-hop and more traditional numbers) make Hamilton a work that should survive in public consciousness for as long as the United States is a nation – and maybe longer. Here are some of the highlights:


